人外周血淋巴细胞用FITC OKT4与红色相关的同型对照。
Human peripheral blood lymphocytes were stained with FITC OKT4 with relevant isotype control in Red.
The OKT4 monoclonal antibody specifically binds to the CD4 receptor for the human immunodeficiency virus (HIV). CD4 is a 59 kDa single-chain transmembrane glycoprotein that expressed on the surface of most of the thymocytes, T-helper cells, and in low levels on monocytes and macrophages. CD4 is a co-receptor in the antigen-induced T cell activation (together with the MHC class II). The OKT4 and the RPA-T4 monoclonal antibodies recognize different epitopes of CD4 and they do not exhibit cross-block binding.
OKT4单克隆抗体特异性结合CD4受体为人类免疫缺陷病毒（HIV）。 CD4是一个59 kDa的单链跨膜糖蛋白，其表达的大多数的胸腺细胞，T辅助细胞的表面上，并在低的水平上的单核细胞和巨噬细胞。 CD4是一个共受体在抗原诱导的T细胞活化（第II类MHC在一起）。的OKT4和RPA-T4的单克隆抗体识别的CD4的不同表位和它们不表现出交叉阻断结合。
Clone | OKT4 |
Format: | FITC |
Applications | FC |
Reactivity | Human |
Isotype: | Mouse IgG2b, kappa |
| Research Interest: | Adaptive Immunity |
| Cell Type: | Monocytes and Macrophages, T Cells, Treg cells, Th17 cells |
Preperation: | The product should be stored undiluted at 4°C and should be protected from prolonged exposure to light. Do not freeze. The monoclonal antibody was purified utilizing affinity chromatography and unreacted dye was removed from the product. |
Formulation: | Phosphate-buffered aqueous solution, ≤0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2. |
References: | Reinherz, E. L., Kung, P. C., Goldstein, G., & Schlossman, S. F. (1979). Separation of functional subsets of human T cells by a monoclonal antibody.Proceedings of the National Academy of Sciences, 76(8), 4061-4065. Knapp W (1989) Leucocyte typing IV: white cell differentiation antigens. Oxford University Press, 1989. Bour, S. T. E. P. H. A. N. E., Boulerice, F. R. A. N. C. O. I. S., & Wainberg, M. A. (1991). Inhibition of gp160 and CD4 maturation in U937 cells after both defective and productive infections by human immunodeficiency virus type 1.Journal of virology, 65(12), 6387-6396. |
