Hedgehog（Hh）信号通路调节胚胎发育和成体许多组织器官干细胞的自我更新与增殖。然而，那些在正常发育过程中受到Hh信号通路调节的组织器官，在该信号通路异常时常常发生肿瘤。这些肿瘤包括肝癌、神经胶质瘤、基底细胞癌、横纹肌肉瘤、胰腺癌、小细胞肺癌、胃癌、结肠癌、前列腺癌、黑色素瘤和多发性骨髓瘤等。

Sonic hedgehog (SHh):
Plays an important role in embryonic development and in diseases such as cancer. Antibodies against SHh are useful reagents to investigate the expression and function of SHh.

The hedgehog pathway has drawn great attention recently as a novel therapeutic target for treating certain types of cancer. StemRD has generated a mouse monoclonal antibody against human and mouse SHh. This antibody has nM binding affinity to SHh protein, and importantly, is functionally blocking against human and mouse SHh. Data shown below is from an activity assay for inhibition of human SHh.

Fig. 1:
A monoclonal antibody against SHh blocks the activity of human SHh. Activity is assessed by a Gli reporter gene assay in Swiss 3T3 cells against 20 ng/mL human SHh (from StemRD).

Purity:
Greater than 95% as determined by SDS-PAGE analysis

Biological Activity:
The activity of this antibody in blocking SHh was determined by using a Gli reporter gene assay in 3T3 cells. The IC50 for inhibiting SHh-induced activation ranges 1 to 5 nM.

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